Molecular population genetic analysis of aStreptococcus pyogenesbacteriophage-encoded hyaluronidase gene: recombination contributes to allelic variation
AM Marciel, V Kapur, JM Musser - Microbial pathogenesis, 1997 - Elsevier
Many strains of the human pathogenic bacteriumStreptococcus pyogenesproduce
hyaluronidase, an enzyme that degrades hyaluronic acid, a major component of the
extracellular matrix. Degradation of hyaluronic acid is thought to aid in host tissue invasion
and dissemination ofS. pyogenes. The molecular population genetics of the bacteriophage-
encoded hyaluronidase gene (hyl) was analysed by sequencing the gene from 13
streptococcal strains representing seven well-differentiated multilocus enzyme …
hyaluronidase, an enzyme that degrades hyaluronic acid, a major component of the
extracellular matrix. Degradation of hyaluronic acid is thought to aid in host tissue invasion
and dissemination ofS. pyogenes. The molecular population genetics of the bacteriophage-
encoded hyaluronidase gene (hyl) was analysed by sequencing the gene from 13
streptococcal strains representing seven well-differentiated multilocus enzyme …
