Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
A Ullrich, JR Bell, EY Chen, R Herrera, LM Petruzzelli… - Nature, 1985 - nature.com
A Ullrich, JR Bell, EY Chen, R Herrera, LM Petruzzelli, TJ Dull, A Gray, L Coussens, YC Liao…
Nature, 1985•nature.comWe have deduced the entire 1,370-amino-acid sequence of the human insulin receptor
precursor from a single complementary DNA clone. The precursor starts with a 27-amino-
acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme
cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane
sequence. There are sequence homologies to human epidermal growth factor receptor and
the members of the src family of oncogene products.
precursor from a single complementary DNA clone. The precursor starts with a 27-amino-
acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme
cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane
sequence. There are sequence homologies to human epidermal growth factor receptor and
the members of the src family of oncogene products.
Abstract
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor α-subunit, a precursor processing enzyme cleavage site, then the β-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
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